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PGT-SR (structural rearrangements)

Preimplantation genetic testing for structural rearrangements (PGT-SR)

You or your partner have been diagnosed as having an abnormal karyotype (the number and arrangement of the chromosomes within the cells). Either a robertsonian or reciprocal translocation may have been diagnosed or an inversion may have been detected. The presence of this re-arrangement will potentially make it difficult to conceive a healthy pregnancy naturally, and may have already resulted in complete infertility or recurrent miscarriage

Next generation sequencing (NGS) is the most well-established of the available methods for PGT-SR. It allows us to comprehensively screen embryos for abnormalities in all 24 chromosomes before transfer. 90-95% of structural rearrangements can be detected by NGS, the embryologist will be able to confirm the exact testing effectiveness with your particular karyotype by consulting with the genetics lab Igenomix on your behalf.

The process for PGT-SR is the same as standard PGT apart from it is recommended that all PGT-SR cases use ICSI as the method of fertilisation to ensure that there is no extra risk of DNA contamination, that could make the results unreadable. It is also mandatory that all couples embarking on IVF treatment for testing with a known structural rearrangement have consulted a genetic counsellor prior to commencement.

No test is 100% accurate, so following any genetic screening we recommend that patients who become pregnant undergo prenatal screening if deemed appropriate by the obstetric team.

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General enquiries

The Lister Fertility Clinic
The Lister Hospital
Chelsea Bridge Road
London SW1W 8RH

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